Laxogenin Vs. Turkesterone: A Head-to-Head Comparison
There are lots of natural supplements that promise to help enhance muscle growth, strength, and recovery, all without causing damage to your liver, cardiovascular system, and other organs. Examples of such supplements include laxogenin and turkesterone.
While they serve the same purpose, there are some aspects that make the two slightly different from each other. Below, we compare laxogenin vs. turkesterone to help you make an informed decision when choosing between the two plant-based hormones.
Laxogenin Vs. Turkesterone: What’s the Difference?
What Is Laxogenin?
Laxogenin belongs to a class of plant hormones called brassinosteroid. These plant-based steroid hormones promote growth in plants. The primary sources of laxogenin are Smilax sieboldii and Allium chinense plants, which are native to Asia.
Laxogenin has a similar chemical structure to human sex hormones, such as testosterone. But it doesn’t trigger anabolism via androgen receptor activity as testosterone does. It instead uses different action mechanisms that may:
- Promote protein synthesis
- Prevent muscle breakdown
- Increasing cAMP levels
- Companies market laxogenin and its derivative, hydroxy-laxogenin, as natural dietary supplements.
What Is Turkesterone?
Turkesterone is an ecdysteroid — a class of steroid hormones derived from plants and insects. Insects use ecdysteroids to shed and replace their exoskeletons, while plants produce them to ward off predators. Turkesterone comes mainly from the Ajuga turkestanica plant. But it’s also available in negligible amounts in spinach and yams.
Turkestanica extract works pretty much like laxogenin in that it doesn’t bind to androgen receptors. It, instead, activates the estrogen receptor beta responsible for boosting skeletal muscle growth and repair.
Pros and Cons of Using Laxogenin
|The Pros||The Cons|
|Enhances muscle growth: Laxogenin promotes muscle protein synthesis by activating protein kinase B or AKT1. This anabolic protein helps build muscle mass while preventing muscle protein disintegration (atrophy).||There’s no scientific evidence to back up most claims made by laxogenin users. That's because there are no animal or human studies conducted on the supplement.|
|Reduces body fat: Natural laxogenin inhibits the enzyme that breaks up cAMP (phosphodiesterase), resulting in an increase in cAMP levels. An increase in cAMP levels in the body causes the breakdown of glycogen stores in the muscles. This eventually results in fat loss.||The Federal Drug Administration (FDA) has not approved the use of laxogenin as a dietary supplement. In fact, hydroxy-laxogenin appears on the DOD Prohibited Dietary Supplement Ingredients list.|
|Accelerates muscle recovery: The stress hormone cortisol can delay muscle recovery, especially after a hard workout. High cortisol levels can also stop muscle growth. Laxogenin inhibits cortisol, thus promoting quick post-workout recovery.||Most products labeled as containing laxogenin or hydroxy-laxogenin often contain the synthetic version of these compounds. They may also contain other substances not disclosed on the label.|
|No need for post-cycle therapy: Laxogenin does not raise your hormone levels beyond natural levels. It also doesn’t affect your hypothalamic-pituitary-testicular axis. That means you won’t need post-cycle therapy after running a laxogenin cycle. Therefore, you can use laxogenin during your off-cycle period.|
|It’s stackable: You can stack laxogenin with other supplements for compounded anabolic effects. Unlike the old method that involves stacking several testosterone boosters, this unique approach activates different anabolic pathways that help build muscle mass. This gives the supplement an edge in the laxogenin vs. turkesterone debate.|
Does Laxogenin Have Any Side Effects?
The supplement’s safety is unclear because of the lack of human clinical trials. Anecdotal reports from users, however, suggest that high doses of laxogenin may cause headaches.
Is Laxogenin Legal?
Yes, it’s 100 percent legal. Athletes and fitness enthusiasts can buy it over the counter without fear of breaking the law.
Pros and Cons of Using Turkesterone
Some of the beneficial effects of turkesterone include the following:
1. Ability to increase lean muscle mass gains
The Ajuga turkestanica extract supports muscle development by promoting protein synthesis. To boost protein synthesis, the extract optimizes mRNA translation.
A muscle cell decodes information from the messenger RNA (mRNA) and uses it to create a protein or a sequence of essential amino acids. The proteins and amino acids are the building blocks of big, strong, and defined muscles.
Turkesterone also blocks proteins such as myostatin protein and the stress hormone cortisol that hinder muscle development.
2. Aids in fat loss
Turkesterone speeds up the metabolism of lipids and carbohydrates, contributing to fat and weight loss. The good news is you’ll still maintain muscle gains during fat loss. That’s because this extract promotes nitrogen retention in your muscles. A positive nitrogen balance prevents muscle breakdown.
3. Increases strength, energy, and endurance
This natural muscle builder promotes the production of Adenosine triphosphate (ATP) in the muscle cells. Acting as your body’s internal fuel shuttle, ATP delivers the energy needed by your muscle cells to boost strength and power and ease muscle fatigue. This ultimately helps enhance performance, which is necessary to build muscle mass.
4. Faster post-workout recovery
A hard workout is likely to cause sore muscles. That’s because the muscles and the respective connective tissues suffer micro tears, stimulating an inflammatory response.
Turkesterone promotes faster repair of muscle tears and eases inflammation. It also reduces cortisol levels in your bloodstream. High cortisol levels slow down muscle recovery after exercise. All these actions promote faster post-workout recovery.
5. Fast acting
The effects of a turkesterone supplement kick in pretty fast. According to anecdotal evidence, you should start seeing an increase in muscle endurance and subsequent fitness gains after only four weeks of use.
6. Suits both men and women
This muscle-building supplement can be used by both men and women. That’s because it doesn’t affect hormone production as synthetic steroids do. So women don’t have to fear getting virilization symptoms such as facial hair growth, deepening of the voice, or menstrual cycle interruptions.
7. No need for Post-Cycle Therapy (PCT)
Turkesterone has similar effects as testosterone. And unlike anabolic steroids, it does not interfere with the natural production of testosterone and androgens. This means that you can run subsequent cycles of turkesterone without the need for post-cycle therapy.
8. You can stack it.
You can use turkesterone with other supplements, such as testosterone boosters, muscle-building supplements, or fat-loss supplements, to get amplified effects depending on your fitness goal.
- Turkesterone supplements are expensive.
- Some products contain less of the active ingredient (turkesterone extract). So, they may not be as potent or effective as expected.
Does Turkesterone Have Any Possible Side Effects?
Animal studies and anecdotal evidence show that turkesterone has a great safety profile. Unlike anabolic steroids, it doesn’t raise your androgen levels or suppress the body’s capacity to produce testosterone. As a result, you won’t experience adverse side effects like high blood pressure, stroke, or liver and kidney toxicity, usually caused by hormonal imbalance.
That said, most users report some mild side effects when they take the supplement on an empty stomach. High doses may also cause discomfort in the form of:
- Stomach upset
Therefore, you should always take your daily dose after meals. You should also not exceed the recommended dose of 500mg to 1,000mg daily serving.
Is Turkesterone Legal?
Yes, turkesterone is legal—you can buy this dietary supplement in physical stores or online. Athletes can use it to enhance their performance in sanctioned competitions since it’s not been banned by World Anti-Doping Agency (WADA).
Laxogenin Vs. Turkesterone: The Bottom-line
In the debate of laxogenin vs. turkesterone, turkesterone shows a competitive edge over laxogenin. Unlike laxogenin, which doesn’t have clinical trials in animals or humans, turkesterone has lots of scientific evidence backing up its muscle-building benefits and safety profile.
That said, the two supplements can be safely stacked together to increase your chances of getting lean muscle mass, strength, and energy.